Hemostatic function of aspirin-treated platelets vulnerable to cardiopulmonary bypass

Activation of the hemostatic system during cardiopulmonary bypass.

Cardiopulmonary bypass (CPB) is a unique clinical scenario that results in widespread activation of the hemostatic system. However, surgery also results in normal increases in coagulation activation, platelet activation, and fibrinolysis that are associated with normal wound hemostasis. Conventional CPB interferes with normal hemostasis by diluting hemostatic cells and proteins, through reinfus...

Platelet function defects related to cardiopulmonary bypass.

Synergic effects of Summer Savory extract and aspirin on human platelets function

Introduction: Cardiovascular disease is one of the most common diseases in the world. In this account, atherosclerosis is one of the main cause’s heart attacks. Coagulation activity of platelets plays an important role in atherosclerotic plaque formation, thrombosis formation and cardiovascular diseases. Aspirin is the most commonly drugs which used as anti-platelet function to prevent and trea...

The Response of Hemostatic Marker Levels to Activated Factor VII in a Neonate following Cardiopulmonary Bypass

The primary function of recombinant activated factor VII (rFVIIa) is to increase thrombin formation which leads to increased fibrin and less "bleeding." As a result, most of literature utilizes "bleeding" as the outcome measure with respect to rFVIIa. However, we report the actual effect of rFVIIa on changes in hemostatic markers such as prothrombin activation peptide F1.2, thrombin antithrombi...

The platelet function defect of cardiopulmonary bypass.

The use of cardiopulmonary bypass (CPB) during cardiac surgery is associated with a hemostatic defect, the hallmark of which is a markedly prolonged bleeding time. However, the nature of the putative platelet function defect is controversial. In this study, blood was analyzed at 10 time points before, during, and after CPB. We used a whole-blood flow cytometric assay to study platelet surface g...